Hamilton, Greinke remain on market after meetings


NASHVILLE, Tenn. (AP) — As baseball's new Mr. Moneybags, Ned Colletti gets mentioned when almost any free agent is discussed this offseason.


"There's a perception that we're in on a couple dozen starting pitchers, three dozen outfielders and infielders, 17, 18 catchers," the Los Angeles Dodgers general manager said.


"People like to have us in. I guess it doesn't hurt to have us in, even though we're not in. We may have to hire somebody next year just to tell everybody who we're not in on," he said.


As teams headed home from the winter meetings Thursday, the biggest free agents were still on the market. The availability of slugger Josh Hamilton and pitcher Zack Greinke held up decisions on other signings and possible trades involving on Rangers star Michael Young and the Mets' Cy Young Award winner R.A. Dickey.


The Yankees, quiet thus far, were pursuing former Boston star Kevin Youkilis and also met with the agent for Mark Reynolds.


With most clubs already packed up and leaving the sprawling, 2,881-room Opryland hotel, Philadelphia acquired outfielder Ben Revere from Minnesota for right-handers Vance Worley and Trevor May.


Hamilton could remain with Texas, and Seattle seemed to be interested. Greinke's options include staying with the Los Angeles Angels, moving up the coast to the Dodgers or signing with the Rangers.


Mariners general manager Jack Zduriencik said that after taking in information from other clubs and agents, it was time to return home and "cool your jets."


"There can be a domino affect," he said. "I think when clubs are focusing on a certain position, a certain need, there's options out there. And once one option goes away, then that changes the landscape of what a club would want to do. Everybody's got their ducks lined up in a row, and it's just a matter of how things fall. And there's timing involved."


The annual meeting wasn't much of a swap session. The Phillies-Twins deal was just the fourth trade over the four days.


Atlanta announced a one-year deal with outfielder Reed Johnson on Thursday, and Texas said reliever Koji Uehara had reached an agreement with Boston.


But the 25-foot wide dais with a podium backed by MLB logos was used just three times: Yankees general manager Brian Cashman discussed Alex Rodriguez's hip injury; Major League Baseball announced an auction benefiting Stand Up to Cancer; and the Mets talked about David Wright's $138 million, eight-year contract, which had been agreed to last week.


The Yankees have been quiet, watching as catcher Russell Martin agreed with Pittsburgh last week and backup third baseman Eric Chavez went to Arizona during the meetings. Wanting to get under the $189 million luxury tax threshold in 2014, the Yankees are being cautious. Still, Cashman maintained it hasn't been a rough week for him.


"Because I don't read the papers as much as I used to," he said. "This year's marketplace, it might be strong in terms of the dollars being thrown around, but I don't think it's a strong market in terms of the available talent."


As the meetings ended, Cashman had made a $12 million offer to Youkilis, who would play third base while A-Rod recovers. The Phillies were trying to obtain Young, the infielder who has been with the Rangers for his entire 13-season career and would have to approve a trade. Arizona was listening to offers for outfielder Justin Upton.


"It seems like when people leave the winter meetings, there's a bit of a quiet period," Red Sox GM Ben Cherington said. "People kind of get out of the frenzy, maybe take a step back and realize that maybe something they were talking about isn't such a good idea. Sometimes things get close and never end up happening."


For all the talk, the Dodgers have made only one big move since the end of the season, re-signing closer Brandon League. But they've been quite busy over 2012. After they were bought in May for $2 billion by a group headed by Mark Walter and Stan Kasten, Los Angeles added stars Hanley Ramirez, Adrian Gonzalez, Carl Crawford and Josh Beckett. The Dodgers face a Sunday deadline to reach a deal with South Korean pitcher Ryu Hyun-Jin, whose rights they gained for a $25.7 million bid.


Quite different from the days under the previous owner, Frank McCourt.


"You couldn't get an agent to return a phone call," Colletti said. "Now you've got them lined out the door."


Texas GM Jon Daniels was popular, too, given his interest in Hamilton and Greinke, and talks involving Upton and a possible a multi-team trade.


"It just makes it tougher, more than two clubs," he said, adding he had a variety of trade and free-agent options. "There are a couple of big decisions that are going to impact the direction. We've narrowed it down, but there's still a couple ways we can go. Some of that is up to us, and some of that is up to the guys on the other side of the table."


After exploring trades involving Dickey, Mets GM Sandy Alderson said it was possible the team could keep the knuckleballer without a deal for beyond 2013.


"I don't think it's necessarily the optimum result, but it's a possible result," he said.


Some teams worry about overpaying this early in the offseason. Other clubs conclude they must.


"You run into people, like, 'Man, I didn't want to do that, but I had no choice,'" Cashman said. "So they're getting a problem solved, but they're not happy with their solution and what they had to do to solve it. I don't want to be in that position. I'd rather feel good about what I'm doing."


NOTES: The winter meetings will return to Nashville in 2015, the governing body of the minor leagues announced. Next year's meetings are in Lake Buena Vista, Fla., and the 2014 session is in San Diego.


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Kristen Wiig may join “Anchorman: The Legend Continues”












LOS ANGELES (TheWrap.com) – Kristen Wiig is being eyed for a role in “Anchorman: The Legend Continues” for Paramount Pictures, a person familiar with the negotiations has told TheWrap.


Wiig would play opposite Steve Carell, as a love interest in the sequel. The script is still being written, and no cast beyond the principals has been set.












Adam McKay is directing the feature, which is being produced by Judd Apatow through his Apatow Productions banner. The film is a sequel to the 2004 hit, “Anchorman: The Legend of Ron Burgundy” and is due to be released in October 2013.


Best known for her work on “Saturday Night Live,” Wiig is one of the most in-demand actresses in Hollywood, since appearing in the film “Bridesmaids.” She could recently be seen at the Toronto International Film Festival in the indie feature “Imogene,” and has been busy filming a number of titles, including “The Secret Life of Walter Mitty,” and “Hateship Friendship,” with Guy Pearce.


“Anchorman: The Legend Continues” will see the original film’s cast return, including Will Ferrell, Christina Applegate, Paul Rudd and Carell. The story follows the on-set adventures of San Diego’s top newsman who is played by Ferrell. “Anchorman: The Legend of Ron Burgundy” made around $ 85 million at the box office.


Movies News Headlines – Yahoo! News


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Celebrations planned as Wash. legalizes marijuana


SEATTLE (AP) — Legal marijuana possession becomes a reality under Washington state law on Thursday, and some people planned to celebrate the new law by breaking it.


Voters in Washington and Colorado last month made those the first states to decriminalize and regulate the recreational use of marijuana. Washington's law takes effect Thursday and allows adults to have up to an ounce of pot — but it bans public use of marijuana, which is punishable by a fine, just like drinking in public.


Nevertheless, some people planned to gather at 12:01 a.m. PST Thursday to smoke in public beneath Seattle's Space Needle. Others planned a midnight party outside the Seattle headquarters of Hempfest, the 21-year-old festival that attracts tens of thousands of pot fans every summer.


"This is a big day because all our lives we've been living under the iron curtain of prohibition," said Hempfest director Vivian McPeak. "The whole world sees that prohibition just took a body blow."


In another sweeping change for Washington, Gov. Chris Gregoire on Wednesday signed into law a measure that legalizes same-sex marriage. The state joins several others that allow gay and lesbian couples to wed.


That law also takes effect Thursday, when gay and lesbian couples can start picking up their wedding certificates and licenses at county auditors' offices. Those offices in King County, the state's largest and home to Seattle, and Thurston County, home to the state capital of Olympia, planned to open the earliest, at 12:01 a.m. Thursday, to start issuing marriage licenses. Because the state has a three-day waiting period, the earliest that weddings can take place is Sunday.


The Seattle Police Department provided this public marijuana use enforcement guidance to its officers via email Wednesday night: "Until further notice, officers shall not take any enforcement action — other than to issue a verbal warning — for a violation of Initiative 502."


Thanks to a 2003 law, marijuana enforcement remains the department's lowest priority. Even before I-502 passed on Nov. 6, police rarely busted people at Hempfest, despite widespread pot use, and the city attorney here doesn't prosecute people for having small amounts of marijuana.


Officers will be advising people to take their weed inside, police spokesman Jonah Spangenthal-Lee wrote on the SPD Blotter. "The police department believes that, under state law, you may responsibly get baked, order some pizzas and enjoy a 'Lord of the Rings' marathon in the privacy of your own home, if you want to."


Washington's new law decriminalizes possession of up to an ounce for those over 21, but for now selling marijuana remains illegal. I-502 gives the state a year to come up with a system of state-licensed growers, processors and retail stores, with the marijuana taxed 25 percent at each stage. Analysts have estimated that a legal pot market could bring Washington hundreds of millions of dollars a year in new tax revenue for schools, health care and basic government functions.


But marijuana remains illegal under federal law. That means federal agents can still arrest people for it, and it's banned from federal properties, including military bases and national parks.


The Justice Department has not said whether it will sue to try to block the regulatory schemes in Washington and Colorado from taking effect.


"The department's responsibility to enforce the Controlled Substances Act remains unchanged," said a statement issued Wednesday by the Seattle U.S. attorney's office. "Neither states nor the executive branch can nullify a statute passed by Congress" — a non-issue, since the measures passed in Washington and Colorado don't "nullify" federal law, which federal agents remain free to enforce.


The legal question is whether the establishment of a regulated marijuana market would "frustrate the purpose" of the federal pot prohibition, and many constitutional law scholars say it very likely would.


That leaves the political question of whether the administration wants to try to block the regulatory system, even though it would remain legal to possess up to an ounce of marijuana.


Colorado's measure, as far as decriminalizing possession goes, is set to take effect by Jan. 5. That state's regulatory scheme is due to be up and running by October 2013.


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Johnson can be reached at https://twitter.com/GeneAPseattle


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Actor Stephen Baldwin charged in NY tax case


WHITE PLAINS, N.Y. (AP) — Actor Stephen Baldwin was charged Thursday with failing to pay New York state taxes for three years, amassing a $350,000 debt.


Rockland County District Attorney Thomas Zugibe said Baldwin, of Upper Grandview, skipped his taxes in 2008, 2009 and 2010.


The youngest of the four acting Baldwin brothers pleaded not guilty at an arraignment and was freed without bail. His lawyer, Russell Yankwitt, said Baldwin should not have been charged.


"Mr. Baldwin did not commit any crimes, and he's working with the district attorney's office and the New York State Tax Department to resolve any differences," Yankwitt said.


The district attorney said Baldwin could face up to four years in prison if convicted. The actor is due back in court on Feb. 5.


Zugibe said Baldwin owes more than $350,000 in tax and penalties.


"We cannot afford to allow wealthy residents to break the law by cheating on their taxes," the district attorney said. "The defendant's repetitive failure to file returns and pay taxes over a period of several years contributes to the sweeping cutbacks and closures in local government and in our schools."


Thomas Mattox, the state tax commissioner, said, "It is rare and unfortunate for a personal income tax case to require such strong enforcement measures."


Baldwin, 46, starred in 1995's "The Usual Suspects" and appeared in 1989's "Born on the Fourth of July." He is scheduled to appear in March on NBC's "The Celebrity Apprentice."


His brothers Alec, William and Daniel are also actors.


A bankruptcy filing in 2009 said Stephen Baldwin owed $1.2 million on two mortgages, $1 million in taxes and $70,000 on credit cards.


In October, Baldwin pleaded guilty in Manhattan to unlicensed driving and was ordered to pay a $75 fine. Earlier this year, he lost a $17 million civil case in New Orleans after claiming that actor Kevin Costner and a business partner duped him in a deal related to the cleanup of the 2010 Gulf of Mexico oil spill. The actors and others had formed a company that marketed devices that separate oil from water.


Baldwin co-hosts a radio show with conservative talk figure Kevin McCullough.


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Local sales of homes in foreclosure jump 65% in 3Q




















Remember the winter of 2010-11, and the Groundhog Day blizzard that dumped more than 21 inches of snow on Chicago? Rochelle McIntosh remembers it all too well.














































Sales of Chicago-area homes in the foreclosure process but not yet repossessed by banks soared during the third quarter, RealtyTrac reported Thursday.

The online foreclosure marketplace said 3,531 pre-foreclosure homes in the greater Chicago area sold in the three months that ended in September, up 34 percent from the second quarter and 65 percent year-over-year. Separately, third-quarter sales of repossessed, bank-owned properties rose to 5,731 properties, up 37 percent from June and 45 percent from 2011's third quarter.






Increased sales of distressed homes are a good sign for the market's long-term health because overall prices will rise as discounted properties are removed from the market. Also, the increase in pre-foreclosure short sales has enabled homeowners to benefit from the Mortgage Forgiveness Debt Relief Act, which does not treat the forgiven part of the unpaid debt as taxable income. The legislation is set to expire at year's end.

Natiionally, the 98,125 pre-foreclosure short sales completed during the third quarter just outnumbered the sale of 94,934 bank-owned properties.

"The shift toward earlier disposition of distressed properties continued in the third quarter as both lenders and at-risk homeowners are realizing that short sales are often a better alternative than foreclosure," said Daren Blomquist, a RealtyTrac vice president.

However, he added, "The prospect of being taxed on potentially tens or hundreds of thousands of dollars in additional income may motivate more distressed homeowners to forgo a short sale and allow the home to be foreclosed."

On average, Chicago-area homes sold through short sales, a transaction where the homeowner sells the property for less than the amount owed on the mortgage, with the bank's permission, sold for an average discount of 41 percent from non-distressed sales. Bank-owned homes sold at an average discount of 54 percent.

RealtyTrac said sales of distressed properties accounted for 28 percent of Chicago-area home sales during the third quarter. The company's definition of the Chicago area extends from southern Wisconsin to Northwest Indiana.

mepodmolik@tribune.com | Twitter @mepodmolik




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Cops: State senator tried to board plane with unloaded gun, clip









State Sen. Donne Trotter, who is seeking the congressional seat vacated by Jesse Jackson Jr., was arrested this morning at O’Hare International Airport for attempting to board a plane with an unloaded handgun and a clip with six bullets, officials said.

Trotter, a Chicago Democrat who has served in the state legislature since 1988, was charged with a Class 4 felony, according to a spokeswoman for the Cook County state’s attorney’s office.

A Chicago police officer responded to a call of a handgun that showed on an X-ray machine at Checkpoint No. 2 in Terminal 1 around 7 a.m., police said. When police and an agent from the Transportation Security Administration realized the bag belonged to Trotter, they escorted him to a nearby room to interview him, police said.

Authorities found a .25-caliber Beretta in his garment bag, and a clip containing six live rounds in a separate side pocket, according to police, who said the gun was not loaded.

Trotter told police he worked late Tuesday night at his job as a security guard for All Points Security and packed his bag early this morning, police said. They said he told authorities he didn’t realize the gun was in the bag.

The gun is the same one he uses for work, police said. He has a valid Firearm Owner’s Identification Card and has a permit with the Illinois Department of Financial and Profession Regulation to work as a security guard, police said.

Trotter, 62, will spend the night in a Northwest Side police lockup before appearing for a bond hearing Thursday.

The TSA released a statement saying passengers who bring a firearm through an airport checkpoint face criminal prosecution and penalties up to $7,500. "Passengers may only transport firearms, ammunition and firearm parts in checked bags," it said. "Firearms must be unloaded, properly packed in a hard-sided container, and declared to the airline during the ticket counter check-in process."

Trotter is among more than a half-dozen announced and potential contenders for the Democratic nomination for the South Side and south suburban congressional seat that Jackson resigned from late last month. The lead state budget negotiator among state Senate Democrats, Trotter was not in Springfield during the Senate’s session today.

Trotter had been viewed as the most likely contender among the field to receive the endorsement of the Cook County Democratic Party in a slating session scheduled for Dec. 15. Trotter already received the backing of the Democratic chairmen in Thorton and Bremen townships in suburban Cook County.

In the 2nd Congressional District, which stretches from the South Side to include parts of Will and all of Kankakee counties, the bulk of the Democratic votes are cast in the Cook County suburbs.

The field of announced Democratic contenders also includes former one-term U.S. Rep. Debbie Halvorson of Crete, who lost to Jackson in the March primary, state Sen. Toi Hutchinson of Olympia Fields, former state Rep. Robin Kelly of Matteson, state Sen.-elect Napoleon Harris of Flossmoor and disgraced former U.S. Rep. Mel Reynolds.

Tribune reporters Monique Garcia and Annie Sweeney contributed.

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Apple shares tumble 4 percent in heavy trade


NEW YORK/SAN FRANCISCO (Reuters) - Shares of Apple Inc tumbled nearly 4 percent on Wednesday, rounding off a bleak ten weeks for the most valuable U.S. company, with analysts citing factors such as increasing competition in the tablet market.


The stock was one of the biggest percentage losers on the S&P 500, dropping 5.2 percent to $545.56 at one point as more than 17 million shares changed hands, putting it on track to surpass the company's average daily volume over 50 days of 21 million shares.


The stock's massive size meant the retreat was responsible for two-thirds of the 1.1 percent decline in the Nasdaq 100 Index on Wednesday.


Analysts gave different reasons for the decline. Some cited a research report saying the company will lose share in the tablet computer space next year. Others cited reports of higher margin requirements at clearing firms, and several investors said uncertain tax rates on capital gains in 2013 prompted selling.


"Depending on what happens with the (U.S. fiscal negotiations), rates could rise next year or they could stay the same," Brian Battle, director of trading at Performance Trust Capital Partners in Chicago, said. "They will not be lower, so if you're an investor who has seen gains in Apple, it is better to take those gains this year rather than next."


Apple is still up 36 percent so far this year, but has been weak recently, dropping into bear market territory. The stock is now down nearly 22 percent from its all-time high of $705.07 a share of September 21.


Some were perplexed at the sudden falling out of favor of the stock, which so far has been a staple in almost all growth portfolios.


"Apple stock is significantly more volatile than its earnings and innovation stream," Daniel Ernst, analyst with Hudson Square Research said. "And yet the wind blows slightly from the south instead of the east one particular morning and the stock is down 6 percent."


"It makes no sense. There are lines around the block for their products all around the world," he added. "No other company has that."


On Wednesday, research firm International Data Corp said Apple would shed market share in the tablet computer space for all of 2012, with consumers favoring devices that run on Google's Android platform instead of Apple's popular iPad product line.


Apple's worldwide tablet market share would slip to 53.8 percent in 2012 from 56.3 percent in 2011, while Android products would increase their share to 42.7 percent from 39.8 percent, IDC said.


The main reason for the negative sentiment around the stock is likely concerns about new competition in the tablet market, Colin Gillis, an analyst with BGC Partners, adding that some investors who were hoping for a special dividend this year may be disappointed as time is running out.


"If you were expecting special dividend by year end, that's less likely to happen because its December 5," he said.


TAX SELLING


Separately, Nokia is to partner with China Mobile, the world's biggest mobile operator, in a sales deal that will give the Finnish company an opportunity to win back Chinese market share from Apple's iPhone.


"This is not going to be a short-term trend. This is a management test, of how well they can perform without (deceased former chief executive) Steve Jobs," said Battle.


Referring to one of Apple's most recent product launches, a version of the iPad that was smaller but not a new product category, Battle said Apple would need "another home run" for shares to return to levels around $700.


"They need another new product that hits it out of the park. Without that, they could get a gradual grind-down in confidence," he said.


The 7.9-inch iPad mini marks Apple's first foray into the smaller-tablet segment and is the company's first major new device since the death of co-founder Jobs last year.


While lines for the new iPads had appeared lighter than usual when it hit stores in November, the company said at that time that demand was so strong that it "practically sold out of iPad minis". It said it sold 3 million of its new iPads -- including the newer full-size version -- in the first three days on the market.


Apple is currently ramping up the introduction of its latest iPhone 5 smartphone and smaller iPad mini tablet in international markets. The company is launching the iPhone 5 in 50 countries in December, including China and South Korea.


Some analysts suggested that investors also sold shares of Apple amid uncertainty over ongoing fiscal negotiations in Washington. If no agreement is reached on the issue, higher taxes on dividends and capital gains are possible in 2013. That has prompted some investors to lock in profits now, particularly on a stock like Apple, which has posted gains of at least 25 percent for four consecutive years.


Tax selling "can take a life of its own," said Tim Ghriskey, chief investment officer of Solaris Group in Bedford Hills, New York.


"Some taxable investors take the gains, that creates some negative momentum, institutional investors are heavily weighted the stock and reduce exposure."


(Additional reporting by Charles Mikolajczak in New York and Doris Frankel in Chicago; Editing by Bernadette Baum and Andrew Hay)



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Chiefs players head to Belcher memorial service


KANSAS CITY, Mo. (AP) — Several players for the Kansas City Chiefs attended a memorial service for teammate Jovan Belcher, who killed his girlfriend and then fatally shot himself in the head.


Belcher killed 22-year-old Kasandra Perkins on Saturday at the home they shared in Kansas City with their 3-month-old daughter. He then drove to the Chiefs practice facility at Arrowhead Stadium, where he killed himself in front of team officials, who pleaded with him to put down his gun.


Retired Chiefs Hall of Famer Bobby Bell said after the private hour-long service that general manager Scott Pioli, who witnessed Belcher's suicide, spoke during the service. Bell said an uncle of Belcher also spoke.


The service was held at a church that Belcher and Perkins attended.


Several other Chiefs players declined comment after the service.


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Kathie Lee Gifford’s “Scandalous” musical to close after three weeks












LOS ANGELES (TheWrap.com) – So much for Kathie Lee Gifford‘s career as a playwright. The former “Live!” co-host’s Broadway musical “Scandalous: The Life and Times of Aimee Semple McPherson,” is shuttering a little after three weeks after it opened.


The musical, which opened November 15, will have its final performance December 9 at the Neil Simon Theatre in New York.












Gifford wrote the book and lyrics for “Scandalous,” which chronicled the life of evangelist and proto-celebrity Aimee Semple McPherson, who rose to prominence in the 1920s, only to fall from public grace amid scandalous love affairs and other controversies.


In all, “Scandalous” will have played 29 regular performances before it goes dark and 31 previews. The musical stars Carolee Carmello (left) and George Hearn, among others, and is directed by David Armstrong (“A Christmas Story the Musical,” “Catch Me if You Can”).


Though Gifford had ample opportunity to plug the production via her “Today” co-hosting duties – and she certainly took advantage of the opportunity – critics were generally unkind in their appraisal of the show.


“‘Scandalous’ isn’t so much scandalously bad as it is generic and dull,” wrote the New York Times’ Charles Isherwood.


Newsday’s Linda Winer took specific aim at Gifford’s “bombardment of nursery-rhyme lyrics.”


Talkin’ Broadway’s Matthew Murray, meanwhile, scoffed that the play “is not distinctive in one positive way.”


Music News Headlines – Yahoo! News


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Study could spur wider use of prenatal gene tests


A new study sets the stage for wider use of gene testing in early pregnancy. Scanning the genes of a fetus reveals far more about potential health risks than current prenatal testing does, say researchers who compared both methods in thousands of pregnancies nationwide.


A surprisingly high number — 6 percent — of certain fetuses declared normal by conventional testing were found to have genetic abnormalities by gene scans, the study found. The gene flaws can cause anything from minor defects such as a club foot to more serious ones such as mental retardation, heart problems and fatal diseases.


"This isn't done just so people can terminate pregnancies," because many choose to continue them even if a problem is found, said Dr. Ronald Wapner, reproductive genetics chief at Columbia University Medical Center in New York. "We're better able to give lots and lots of women more information about what's causing the problem and what the prognosis is and what special care their child might need."


He led the federally funded study, published in Thursday's New England Journal of Medicine.


A second study in the journal found that gene testing could reveal the cause of most stillbirths, many of which remain a mystery now. That gives key information to couples agonizing over whether to try again.


The prenatal study of 4,400 women has long been awaited in the field, and could make gene testing a standard of care in cases where initial screening with an ultrasound exam suggests a structural defect in how the baby is developing, said Dr. Susan Klugman, director of reproductive genetics at New York's Montefiore Medical Center, which enrolled 300 women into the study.


"We can never guarantee the perfect baby but if they want everything done, this is a test that can tell a lot more," she said.


Many pregnant women are offered screening with an ultrasound exam or a blood test that can flag some common abnormalities such as Down syndrome, but these are not conclusive.


The next step is diagnostic testing on cells from the fetus obtained through amniocentesis, which is like a needle biopsy through the belly, or chorionic villus sampling, which snips a bit of the placenta. Doctors look at the sample under a microscope for breaks or extra copies of chromosomes that cause a dozen or so abnormalities.


The new study compared this eyeball method to scanning with gene chips that can spot hundreds of abnormalities and far smaller defects than what can be seen with a microscope. This costs $1,200 to $1,800 versus $600 to $1,000 for the visual exam.


In the study, both methods were used on fetal samples from 4,400 women around the country. Half of the moms were at higher risk because they were over 35. One-fifth had screening tests suggesting Down syndrome. One-fourth had ultrasounds suggesting structural abnormalities. Others sought screening for other reasons.


"Some did it for anxiety — they just wanted more information about their child," Wapner said.


Of women whose ultrasounds showed a possible structural defect but whose fetuses were called normal by the visual chromosome exam, gene testing found problems in 6 percent — one out of 17.


"That's a lot. That's huge," Klugman said.


Gene tests also found abnormalities in nearly 2 percent of cases where the mom was older or ultrasounds suggested a problem other than a structural defect.


Dr. Lorraine Dugoff, a University of Pennsylvania high-risk pregnancy specialist, wrote in an editorial in the journal that gene testing should become the standard of care when a structural problem is suggested by ultrasound. But its value may be incremental in other cases and offset by the 1.5 percent of cases where a gene abnormality of unknown significance is found.


In those cases, "a lot of couples might not be happy that they ordered that test" because it can't give a clear answer, she said.


Ana Zeletz, a former pediatric nurse from Hoboken, N.J., had one of those results during the study. An ultrasound suggested possible Down syndrome; gene testing ruled that out but showed an abnormality that could indicate kidney problems — or nothing.


"They give you this list of all the things that could possibly be wrong," Zeletz said. Her daughter, Jillian, now 2, had some urinary and kidney abnormalities that seem to have resolved, and has low muscle tone that caused her to start walking later than usual.


"I am very glad about it," she said of the testing, because she knows to watch her daughter for possible complications like gout. Without the testing, "we wouldn't know anything, we wouldn't know to watch for things that might come up," she said.


The other study involved 532 stillbirths — deaths of a fetus in the womb before delivery. Gene testing revealed the cause in 87 percent of cases versus 70 percent of cases analyzed by the visual chromosome inspection method. It also gave more information on specific genetic abnormalities that couples could use to estimate the odds that future pregnancies would bring those risks.


The study was led by Dr. Uma Reddy of the National Institute of Child Health and Human Development.


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Online:


Medical journal: http://www.nejm.org


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Marilynn Marchione can be followed at http://twitter.com/MMarchioneAP


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